Subject(s)
Humans , Male , Child, Preschool , Syphilis, Cutaneous , Alopecia/etiology , Penicillin G Benzathine/therapeutic useABSTRACT
Abstract Syphilis is an infectious disease that has afflicted mankind for centuries, but a recent increase in worldwide incidence has been evidenced. The authors describe a patient with typical lesions of secondary syphilis and moth-eaten alopecia, whose dermoscopic examination demonstrated empty hair follicles, vellus hair, follicular hyperkeratosis, peripheral black dots, dilated and tortuous vessels, reddish brown background, and hypopigmentation of the hair shafts. Furthermore, this case presented an erythematous background more evident than previously described cases.
Subject(s)
Humans , Syphilis, Cutaneous , Dermoscopy , Hair Follicle , Hair , Hair DiseasesABSTRACT
La coinfección entre el Treponema pallidum y el virus de la inmunodeiciencia humana (VIH) altera el curso clínico clásico de la sífilis aumentando la probabilidad de aparición de formas atípicas del secundarismo sifilítico. Entre estas formas se ha descripto a la sífilis elegante, entidad caracterizada por un exantema maculopapuloso descamativo, de aspecto anular, por lo general, con indemnidad de las regiones palmo plantar y de las mucosas. Se presenta un caso de sífilis secundaria, con lesiones típicas por su aspecto y localización, de sifílides elegantes en una paciente con diagnóstico de sida
Co-infection between Treponema pallidum and HIV alters the classic clinical course of syphilis, increasing the likelihood of atypical forms of syphilitic secondaryism. Among these forms, elegant syphilis has been described, an entity characterized by a desquamating maculopapular rash of annular appearance, with indemnity of the palmoplantar surface and mucous regions. Here, we present a case of secondary syphilis with typical lesions of elegant syphillides, in a patient diagnosed with AIDS
Subject(s)
Humans , Female , Adolescent , Syphilis, Cutaneous/diagnosis , Treponema pallidum , HIV Infections/immunology , Acquired Immunodeficiency Syndrome/immunologyABSTRACT
Centella asiatica (Linn.) Urban (Umbelliferae) which is also known as ‘pegaga’ is highly consumed and eaten raw as ‘ulam’ in Malaysia. C. asiatica is used in traditional medicines to treat various health conditions such as rheumatism, inflammation, syphilis, skin diseases and diarrhoea. Various reports exhibited that the crude extracts and isolated bioactive compounds of C. asiatica possessed a broad range of pharmacological activities such as anti-oxidant, anti-diabetic, anti-tumor, wound healing, anti-microbial, anti-inflammatory, immunomodulatory, hepatoprotective and memory enhancing properties. The pharmacological validation on anti-microbial and immunomodulatory of C. asiatica is very limited and several existence review papers related for this plant had not been focused for both activities. This review therefore attempts to combine the existing literature to offer immense scope for researchers engaged in validation of the traditional claims and bioactivities of this plant related with anti-microbial and immunomodulatory potential.
Subject(s)
Centella , Complex Mixtures , Inflammation , Malaysia , Memory , Plants , Rheumatic Diseases , Syphilis, Cutaneous , Wound HealingABSTRACT
La anetodermia es una entidad cutánea benigna, rara e infrecuente, cuya característica es la pérdida localizada de fibras elásticas a nivel de la dermis. Suele observarse en pacientes con síndrome antifosfolípidico, lupus eritematoso sistémico, acné y varicela y de manera inusual como manifestación de una sífilis secundaria. Comunicamos el caso de una mujer con secundario o sifilítico que desarrolló anetodermia posterior a este proceso infeccioso.
Anetoderma is a benign, rare and infrequent cutaneous entity whose characteristic is the localized loss of elastic fibers at the level of the dermis. It is usually observed in patients with antiphospholipid syndrome, systemic lupus erythematosus, acne and varicella and an unusual way as a manifestation of secondary syphilis. We report a case of a woman with syphilitic secondary disease who developed an anetoderma after this infectious process.
Subject(s)
Humans , Female , Adult , Syphilis, Cutaneous/diagnosis , Diagnosis, Differential , Elastic Tissue/physiopathology , Anetoderma/therapy , BiopsyABSTRACT
La sífilis es una enfermedad infectocontagiosa causada por una espiroqueta: el Treponema pallidum. Se transmite por contacto directo (generalmente sexual) con las lesiones cutáneo-mucosas durante el estadio primario y secundario, por vía transplacentaria durante el embarazo o a través del pasaje por el canal uterino y por sangre. Se trata de una enfermedad sistémica con una gran variedad de manifestaciones clínicas. La sífilis secundaria cursa con manifestaciones generales de un síndrome infeccioso inespecífico y lesiones mucocutáneas características. La presentación clínica de los 20 pacientes que se describen en este trabajo es singular ya que solo poseían lesiones en la cavidad oral. Es importante considerar esta patología en el diagnóstico diferencial de lesiones mucosas orales, para realizar un diagnóstico temprano, tratamiento precoz y evitar el contagio, así como siempre descartar la asociación con infección por el retrovirus VIH
Syphilis is a sexually transmitted disease caused by the spirochete bacterium named as Treponema pallidum. Syphilis is transmitted by direct contact (generally non-protect sexual contact) with cutaneous and mucosal lesions during the primary and secondary periods, by trans-placental transmission if the mother develop the infection during pregnancy and by blood. Syphilis is a systemic disease with a wide variety of clinical manifestations. Secondary syphilis is characterized by a nonspecific infectious syndrome and mucocutaneous lesions. Here we describe a serie of 20 patients with secondary syphilis as the unique clinical manifestation. Secondary syphilis should be included in the differential diagnosis of oral cavity mucosal lesions to achieve an early diagnosis and avoid the contagion. Human immunodeficiency virus infection should be always considered
Subject(s)
Humans , Adolescent , Adult , Middle Aged , Syphilis, Cutaneous/therapy , Syphilis/diagnosis , Early Diagnosis , Unsafe Sex , Mouth/injuriesABSTRACT
Summary Syphilis is an infection caused by Treponema pallidum, mainly transmitted by sexual contact. Since 2001, primary and secondary syphilis rates started to rise, with an epidemic resurgence. The authors describe an exuberant case of secondary syphilis, presenting with annular and lichen planus-like lesions, as well as one mucocutaneous lesion. Physicians must be aware of syphilis in daily practice, since the vast spectrum of its cutaneous manifestations is rising worldwide.
Resumo A sífilis é uma infecção causada pela espiroqueta Treponema pallidum, transmitida principalmente por contato sexual. Desde 2001, houve o ressurgimento dessa epidemia, com aumento das taxas de sífilis primária e secundária. Os autores descrevem um caso exuberante de sífilis secundária apresentando lesões cutâneas anulares e lesões que lembram líquen plano, além de uma lesão mucocutânea. Médicos de todas as especialidades devem estar cientes das diversas apresentações de sífilis: o vasto espectro de manifestações cutâneas da sífilis secundária e as crescentes taxas dessa patologia representam um desafio.
Subject(s)
Humans , Male , Syphilis, Cutaneous , Syphilis/diagnosis , Syphilis, Cutaneous/pathology , Syphilis/pathology , Middle AgedABSTRACT
La sífilis maligna, también llamada sífilis nódulo-ulcerativa o lúes maligna, es una infrecuente pero grave forma de secundarismo,1 que en la actualidad se observa asociada a patologías como diabetes, tuberculosis, malnutrición, alcoholismo, drogadicción y pacientes VIH positivos2 . Caracterizada por lesiones cutáneas extensas, polimorfas que pueden ser pápulas, placas, tubérculos redondeados y lesiones ulceronecrónicas con centro cubierto por costras rupioides rodeadas por una halo sobrelevado eritematoso. Tienen escasa repercusión ganglionar y serio compromiso general que pueden comprometer la vida del paciente3 . Se presenta una paciente de 43 años con lesiones ulceronecróticas mutilantes de rápida evolución, con compromiso mucocutáneo. Con sospecha clínica de sífilis secundo-terciaria, se detecta serología reactiva para VIH
Malignant syphilis also called node-ulcerative syphilis or malignant lues, is an unusual but otherwise severe form of secundarism, that at present, is observed associated to pathologies such as diabetes, tuberculosis, malnutrition, alcoholism, drugaddiction, and to HIV positive patients. It is characterized by extended cutaneous polymorphous lesions that can be papules, plates, rounded tuberculous and ulceronecrotic lesions with a center covered by rupioid crusts surrounded by an eritematous overelevated border. They have small nodular involvement and serious general compromise that can expose the patient´s survival. A 43-years old female with mutilant ulceronecrotic lesions with rapid evolution and mucutaneous involvement, is presented. With clinical suspicion of secondary-tertiary syphilis, it was detected reactive serology to HIV infection. The recognition that a large proportion of patients with HIV infection also have syphilis has raised the watchword respect to the interaction between these two diseases.
Subject(s)
Humans , Female , Adult , Syphilis, Cutaneous/therapy , Syphilis Serodiagnosis , AIDS Serodiagnosis , HIV Infections/complications , HIV Infections/therapyABSTRACT
El artículo describe el caso de un paciente de 28 años de edad con antecedente de VIH, quien presentaba múltiples lesiones en la piel y las mucosas, producto de sífilis secundaria, y quien mostraba un amplio espectro de manifestaciones cutáneas características de esta enfermedad.
We describe the case of a 28-year-old patient with HIV history who has multiple skin and mucous lesions that showing a broad spectrum of cutaneous manifestations of secondary syphilis.
Subject(s)
Syphilis, Cutaneous/diagnosis , Treponema pallidum/pathogenicity , HIV/classificationABSTRACT
Abstract Early malignant syphilis is a rare and severe variant of secondary syphilis. It is clinically characterized by lesions, which can suppurate and be accompanied by systemic symptoms such as high fever, asthenia, myalgia, and torpor state. We report a diabetic patient with characteristic features of the disease showing favorable evolution of the lesions after appropriate treatment.
Subject(s)
Humans , Female , Middle Aged , Skin/pathology , Syphilis, Cutaneous/pathology , Syphilis/pathology , Diabetes Mellitus/pathology , Skin Ulcer/pathology , Erythema/pathology , ImmunocompetenceABSTRACT
Abstract: Acquired syphilis can be divided into primary, secondary, latent, and tertiary stages. About 25% of patients with untreated primary syphilis will develop late signs that generally occur after three to five years, with involvement of several organs. The authors present an immunocompetent female who developed a tertiary stage syphilis presenting with long-standing nodular plaques.
Subject(s)
Humans , Female , Adult , Syphilis, Cutaneous/immunology , Syphilis, Cutaneous/pathology , Syphilis/immunology , ImmunocompetenceABSTRACT
Abstract: Syphilis is a sexually transmitted disease caused by Treponema pallidum and divided into three stages according to the duration of the disease: primary, secondary and tertiary. Secondary syphilis has diverse clinical presentations, such as papular-nodular lesions. This presentation is rare, with 15 cases reported in the literature over the past 20 years. We report a case of secondary syphilis with papular-nodular lesions in a healthy 63-year-old patient, who has presented treponema in immunohistochemical examination of the skin lesions.
Subject(s)
Humans , Male , Middle Aged , Syphilis, Cutaneous/pathology , Syphilis/pathology , Penis/pathology , Skin/pathology , Biopsy , Serologic Tests , ImmunohistochemistryABSTRACT
Due to diverse clinical and histopathological presentations, diagnosis of secondary syphilis can occasionally prove challenging. Variable clinical presentations of secondary syphilis in HIV disease may result in an incorrect diagnosis and an inappropriate treatment regimen. Similarly, the histology of secondary syphilitic lesions may show considerable variation, depending on the clinical morphology of the eruption. We report a case of secondary syphilis in an HIV infected patient with cutaneous palmoplantar lesions simulating palmoplantar psoriasis.
.Subject(s)
Adult , Humans , Male , HIV Infections/pathology , Psoriasis/pathology , Syphilis, Cutaneous/pathology , Anti-Bacterial Agents/therapeutic use , Biopsy , Coinfection/drug therapy , Coinfection/pathology , Diagnosis, Differential , Keratoderma, Palmoplantar/drug therapy , Keratoderma, Palmoplantar/pathology , Penicillin G Benzathine/therapeutic use , Syphilis, Cutaneous/drug therapy , Treatment OutcomeABSTRACT
The ongoing human immunodeficiency virus (HIV) infection epidemic coupled with more efficacious and available treatments has led to a larger number of patients living with HIV or AIDS. As a result, skin manifestations related to HIV/AIDS or its therapy have become increasingly more common and are reported to occur in as many as 95% of patients. Herein, we review the most common HIV/AIDS related cutaneous pathologies and classify them into inflammatory, HAART-associated, neoplastic, and infectious manifestations. Cutaneous manifestations should be promptly recognized and treated by physicians and health care personnel in order to provide optimal care.
La epidemia del virus de la inmunodeficiencia humana (VIH) sumado al mayor acceso a terapias antiretrovirales (TARV) han llevado a un aumento del número y la sobrevida de pacientes que viven con esta infección crónica. Se estima que hasta 95% de los pacientes con infección por VIH/SIDA presentarán alguna manifestación cutánea, por lo cual, debemos conocerlas. En la presente revisión se estudiarán las manifestaciones cutáneas de la infección por el VIH/SIDA clasificadas como: manifestaciones inflamatorias, manifestaciones asociadas a la TARV, manifestaciones neoplásicas y manifestaciones infecciosas asociadas a infección por VIH/SIDA (bacterianas, virales, fúngicas y parasitarias). Estas manifestaciones deben ser reconocidas por los médicos y el personal de salud a cargo del tratamiento y control de los pacientes con esta patología crónica.
Subject(s)
Humans , AIDS-Related Opportunistic Infections/etiology , Acquired Immunodeficiency Syndrome/complications , Skin Diseases, Infectious/etiology , Skin Neoplasms/etiology , AIDS-Related Opportunistic Infections/drug therapy , Acquired Immunodeficiency Syndrome/drug therapy , Acquired Immunodeficiency Syndrome/etiology , Angiomatosis, Bacillary/etiology , Anti-Retroviral Agents/adverse effects , Antiretroviral Therapy, Highly Active/adverse effects , Dermatitis, Seborrheic/etiology , Psoriasis/etiology , Sarcoma, Kaposi/etiology , Sarcoma, Kaposi/pathology , Skin Diseases, Infectious/physiopathology , Skin Neoplasms/pathology , Syphilis, Cutaneous/etiologyABSTRACT
INTRODUCTION: Secondary syphilis is a sexually transmitted infection characterized by localized or diffuse mucocutaneous lesions, often with generalized lymphadenopathy with laboratory evidence consistent with syphilis. Condolyma latum is one of the many forms of secondary syphilis and is noted to occur commonly on moist intertriginous areas of the body such as the axilla, web spaces of the toes, genital and perianal regions. CASE REPORT: An 18 year-old man presented with a four-month history of few erythematous pruritic plaques on the penile shaft and multiple moist plaques involving the scalp, face, anterior neck, nape, axilla,anterior abdomen, upper and lower extremities, and scrotum. There are few erythematous scaly patches noted on the palms and soles. Serologic testing confirmed a diagnosis of syphilis and the patient tested negative for human immunodeficiency virus infection. The patient was given a single dose of intramuscular benzathine penicillin G 2.4 million units, with noted flattening of all lesions upon follow-up three months later. CONCLUSION: Condylomata lata, although most commonly found on moist intriginous areas of the axilla, web spaces of the toes, genital and perianal regions, can also involve less commonly affected areas such as the scalp, face, anterior abdomen, and the extremities. A high index of suspicion therefore is warranted to differentiate it from other cutaneous diseases and to prevent progression of the disease by initiating appropriate antibacterial therapy.
Subject(s)
Humans , Male , Adolescent , Anti-Bacterial Agents , Axilla , HIV Infections , Lower Extremity , Lymphadenopathy , Scrotum , Sexually Transmitted Diseases , Syphilis , Syphilis, CutaneousABSTRACT
Malignant syphilis is an uncommon manifestation of secondary syphilis, in which necrotic lesions may be associated with systemic signs and symptoms. Generally it occurs in an immunosuppressed patient, mainly HIV-infected, but might be observed on those who have normal immune response. Since there is an exponential increase in the number of syphilis cases, more diagnoses of malignant syphilis must be expected. We report a case in an immunocompetent female patient.